Harald Schwalbe acts as project leader and member of the steering board. He oversees the progress of the proposed research. He is an expert in NMR-based structural biology of RNA, proteins and their complexes. Within the project his group focuses on the fragment screening by NMR against selected RNA targets, the RNA sample preparation, installation and implementation of in-vitro binding assays, characterisation of binding sites by NMR and the synthesis of hit derivatives.